April - June 2025, Volume 21, Issue 2

Kars MY, Dogan MH, Dikmeer A, Cordan I, Hicret Tekin F, Kizilarslanoglu MC

Coexisting Diagnoses of Iatrogenic Cushing's Syndrome and Pyoderma Gangrenosum Due to Inappropriate Topical Corticosteroid Usage in an Older Patient

Acta Endo (Buc) 2025, 21 (2): 265-271
doi: 10.4183/aeb.2025.265

Corticosteroids are systemically or locally used agents in treating many skin disorders. Besides their benefits within the correct indications, they may also increase many adverse reaction risks. Systemic absorption of topical glucocorticoids may rarely cause Iatrogenic Cushing Syndrome (ICS) in the geriatric population. On the other hand, to the best of our knowledge, ICS cases coexisting with pyoderma gangrenosum (PG) have not been reported before in the geriatric population. Herein, we aimed to present a 67-year-old female patient who developed ICS and was accompanied by PG due to long-term use of topical clobetasol 17-propionate therapy.

Keywords: Iatrogenic Cushing's Syndrome, Pyoderma Gangrenosum.

Correspondence: Merve Yilmaz Kars, MD, University of Health Sciences Türkiye, Konya City Hospital, Department of Internal Medicine, Division of Geriatrics, Konya, Turkiye, E-mail: mleeer.90@gmail.com drmerveyilmazkars@gmail.com