ACTA ENDOCRINOLOGICA (BUC)

Background. In recent years, it has been claimed that non-alcoholoic fatty liver disease (NAFLD) has a negative effect on bone mineral density (BMD) and causes osteoporosis. This study was designed to investigate the relationship between non-alcoholic fatty liver disease and BMD in postmenopausal women. Patients and Methods. This study was designed prospectively: 118 postmenopausal women were included in the study. The study participants were divided into two groups as 59 people with NAFLD and 59 people without NAFLD. The groups were compared in terms of bone mineral density. Results. The mean age of the participants in the study was 59.09 ± 9.22 years. According to the degree of NAFLD adiposity of the participants, 59 people were non-NAFLD (50%), 21 people were grade 1 (17.8%), 34 people were grade 2 (28.8%), and 4 people were grade 3 (3.4%). According to the Femur T score of the participants, 2 (1.7%) were osteoporosis, 34 (28.8%) osteopenia, 82 (69.5%) were normal. According to the L1-L4 T score of the participants, 18 (15.3%) were osteoporosis, 44 (37.3%) osteopenia, 56 (47.5%) normal. There was no statistical difference between the two groups in terms of femoral T score and L1-L4 T score. Age, BMI, GGT negatively affect the femoral T score. Conclusion. We found that there was no difference in BMD between groups with and without NAFLD ultrasonographically, but there was a negative correlation between GGT and Femur T score in the subjects.This data suggest that NAFLD may cause osteoporosis”.

Context. In this study we compared daily calorie restriction, and intermittent calorie restriction in overweight and class 1 obese patients. Findings are these diets correct metabolic parameters and intermittent calorie restriction diet regimen increases muscle strength. Aim. We investigated the effects on metabolic, anthropometric values and muscle in Intermittent Fasting (IF) and Continuous Calorie Restriction (CCR) groups in adult overweight and class 1 obese patients. Material and Methods. The patients were randomly divided into 3 groups: IF group (n=23), CCR group (n=21), and control group (n=22). Fat mass, and basal metabolic rate were recorded. Fat-Free Mass Index (FFMI) was calculated. Handgrip strength was measured. Walking speed test was performed. The 'International Physical Activity Questionnaire was administered to the patients. Weight, body mass index, fat mass, muscle mass, FFMI, waist circumference, right and left arm circumference, right and left calf circumference values decreased significantly and similarly compared to the beginning at the end of 6 months in the IF and CCR groups (p<0.05). A statistically significant increase was found in hand grip strength test measurements in the IF groups. Conclusions. IF and CCR diets enhance metabolic functions while reducing muscle mass. Despite this decrease, the IF diet increases muscular strength.