ACTA ENDOCRINOLOGICA (BUC)

effects of Ultrasonic Coagulation (UC), Bipolar Energy Sealing System (BESS), Intra Operative Nerve Monitoring (IONM) and surgical experience on the complications of thyroid surgery. Method. The data of 1627 patients who underwent thyroid surgery for various indications in our department between 2009 and 2018 were analyzed retrospectively and the effects of different technological devices on complications were investigated. Results. Transient recurrent laryngeal nerve (RLN) palsy was higher between 2009 and 2013, when IONM was not in routine use (p=0.029). There were no significant differences between two energy devices (UC and BESS) in terms of transient or permanent RLN palsy, bleeding, and transient or permanent hypocalcemia. Multivariate analysis showed that young age (0.006), female gender (0.016), surgery type (p<0.001), and lateral neck dissection (p=0.026) are independent risk factors for transient hypocalcemia. Conclusion. The results indicate that there is no superior hemostatic device. IONM and specific branching decrease transient RLN palsy. Female gender, young age, completion thyroidectomy, and lateral neck dissection were independent risk factors for the development of transient hypocalcemia.

Introduction. Blood asprosin levels have been found to be elevated in patients with type 2 diabetes and those with Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD). MAFLD is common in individuals with diabetes. We investigated the relationship between pioglitazone treatment and asprosin levels in patients with diabetes and MAFLD. Materials and Methods. Blood samples were collected from 25 patients diagnosed with diabetes and MAFLD at the time of diagnosis and 6 months after pioglitazone treatment. Additionally, blood samples were collected from 15 healthy volunteers as controls. Results. Compared to the 6-month control after pioglitazone treatment, significant reductions were observed in glucose, HbA1c, AST, ALT, GGT, ALP, and Fib-4 scores. However, no significant difference was detected in asprosin levels. Discussion. The significant decrease in glucose, HbA1c, AST, ALT, GGT, ALP, and Fib-4 scores after pioglitazone treatment indicates that pioglitazone is effective in the treatment of both diabetes and MAFLD. The fact that asprosin levels were not different in patients with diabetes and MAFLD compared to healthy controls suggests that diabetic fatty liver occurs through mechanisms independent of asprosin. Conclusion. These results imply that while pioglitazone is effective in treating both diabetes and MAFLD, its action does not involve modulating asprosin levels.